{"id":1829,"date":"2026-03-18T14:28:14","date_gmt":"2026-03-18T07:28:14","guid":{"rendered":"https:\/\/www.piyawatclinic.com\/?p=1829"},"modified":"2026-03-18T17:48:34","modified_gmt":"2026-03-18T10:48:34","slug":"truth-behind-treatment-resistant-melasma-jp","status":"publish","type":"post","link":"https:\/\/www.piyawatclinic.com\/en\/truth-behind-treatment-resistant-melasma-jp\/","title":{"rendered":"Truth Behind Treatment-Resistant Melasma (Jp)"},"content":{"rendered":"

By Dr. Piyawat POOMSUWAN , Dr. Tiwanun PROMVARANON<\/p>\n\n\n\n

\"\"<\/a> \"\"<\/a> \"\"<\/a><\/p>\n

\u6cbb\u7642\u62b5\u6297\u6027\u30e1\u30e9\u30ba\u30de\u306e\u96a0\u3055\u308c\u305f\u771f\u5b9f<\/p>\n

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\u5f93\u6765\u306e\u30e1\u30e9\u30ba\u30de\u306e\u7406\u89e3<\/h1>\n

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\u771f\u306e\u539f\u56e0\uff1a\u771f\u76ae\u306e\u8001\u5316\u7dda\u7dad\u82bd\u7d30\u80de<\/h1>\n

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2. \u708e\u75c7\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb
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Piyawat Clinic\u306e\u30e1\u30e9\u30ba\u30de\u6cbb\u7642<\/h1>\n

Piyawat Clinic\u3067\u306f\u3001\u30e1\u30e9\u30ba\u30de\u3092\u300c\u76ae\u819a\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u75be\u60a3\u300d\u3068\u3057\u3066\u6cbb\u7642\u3057\u307e\u3059\u3002

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Scientific References
1. Kim JY, et al. Senescent fibroblasts in melasma pathophysiology. Experimental Dermatology. 2018;27(7):719-722.
2. Passeron T. Melasma pathogenesis and influencing factors \u2013 an overview of the latest research. Journal of the European Academy of Dermatology and Venereology. 2013;27(Suppl 1):5-6.
3. Kang HY, et al. The pathophysiology of melasma. Journal of Investigative Dermatology Symposium Proceedings. 2009;14(1):4-8.
4. Grimes PE. Melasma: Etiologic and therapeutic considerations. Archives of Dermatology. 1995;131(12):1453-1457.
5. Torres-\u00c1lvarez B, et al. Histochemical and immunohistochemical study in melasma: Evidence of damage in the basal membrane. American Journal of Dermatopathology. 2011;33(3):291-295.
6. Lee DJ, et al. Defective barrier function in melasma skin. Journal of the European Academy of Dermatology and Venereology. 2012;26(12):1538-1543.
7. Handel AC, Miot LDB, Miot HA. Melasma: A clinical and epidemiological review. Anais Brasileiros de Dermatologia. 2014;89(5):771-782.<\/pre>","protected":false},"excerpt":{"rendered":"
By Dr. Piyawat POOMSUWAN , Dr. Tiwanun PROMVARANON \u6cbb\u7642\u62b5\u6297\u6027\u30e1\u30e9\u30ba\u30de\u306e\u96a0\u3055\u308c\u305f\u771f\u5b9f \u306a\u305c\u9577\u5e74\u6cbb\u7642\u3057\u3066\u3082\u30e1\u30e9\u30ba\u30de\uff08\u809d\u6591\uff09\u306f\u518d\u767a\u3059\u308b\u306e\u304b\uff1f \u30e1\u30e9\u30ba\u30de\u306f\u5358\u306a\u308b\u8272\u7d20\u6c88\u7740\u3067\u306f\u306a\u3044 \u8fd1\u5e74\u306e\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u306b\u3088\u308a\u3001\u30e1\u30e9\u30ba\u30de\u306f\u5358\u306a\u308b\u8868\u76ae\u306e\u8272\u7d20\u6c88\u7740\u3067\u306f\u306a\u304f\u3001\u76ae\u819a\u306e\u69cb\u9020\u7684\u5909\u5316\u3092\u4f34\u3046\u300c\u5149\u8001\u5316\u95a2\u9023\u75be\u60a3\u300d\u3068\u3057\u3066\u7406\u89e3\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002 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\u771f\u76ae\u30ea\u30b8\u30e5\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3 \u3053\u308c\u306b\u3088\u308a\u76ae\u819a\u306e\u5fae\u5c0f\u74b0\u5883\uff08skin microenvironment\uff09\u3092\u6b63\u5e38\u5316\u3057\u307e\u3059\u3002 Piyawat Clinic\u306e\u30e1\u30e9\u30ba\u30de\u6cbb\u7642 Piyawat Clinic\u3067\u306f\u3001\u30e1\u30e9\u30ba\u30de\u3092\u300c\u76ae\u819a\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u75be\u60a3\u300d\u3068\u3057\u3066\u6cbb\u7642\u3057\u307e\u3059\u3002 \u5358\u306b\u8272\u7d20\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u5168\u4f53\u306e\u74b0\u5883\u3092\u6539\u5584\u3059\u308b\u591a\u5c64\u7684\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002 \u304a\u808c\u306e\u72b6\u614b\u3084\u304a\u60a9\u307f\u306f\u4e00\u4eba\u3072\u3068\u308a\u7570\u306a\u308a\u307e\u3059\u3002\u5c02\u9580\u306e\u533b\u5e2b\u306b\u3088\u308b\u8a3a\u5bdf\u3092\u53d7\u3051\u3001\u3042\u306a\u305f\u3060\u3051\u306e\u6700\u9069\u306a\u6cbb\u7642\u30d7\u30e9\u30f3\u3092\u7acb\u3066\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002 Scientific References1. Kim JY, et al. Senescent fibroblasts in melasma pathophysiology. Experimental Dermatology. 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