{"id":1838,"date":"2026-03-18T17:30:39","date_gmt":"2026-03-18T10:30:39","guid":{"rendered":"https:\/\/www.piyawatclinic.com\/?p=1838"},"modified":"2026-03-18T17:49:18","modified_gmt":"2026-03-18T10:49:18","slug":"truth-behind-treatment-resistant-melasma-cn","status":"publish","type":"post","link":"https:\/\/www.piyawatclinic.com\/en\/truth-behind-treatment-resistant-melasma-cn\/","title":{"rendered":"Truth Behind Treatment-Resistant Melasma (Cn)"},"content":{"rendered":"
By Dr. Piyawat POOMSUWAN , Dr.Tiwanun PROMVARANON<\/pre>\n\n\n\n
\"\"<\/a> \"\"<\/a> \"\"<\/a><\/p>\n
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1. \u63a7\u5236\u9ed1\u8272\u7d20\u751f\u6210
2. \u63a7\u5236\u708e\u75c7\u53cd\u5e94
3. \u771f\u76ae\u5c42\u5e74\u8f7b\u5316

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Piyawat Clinic\u7684\u6cbb\u7597\u7406\u5ff5<\/h1>\n
\u5728Piyawat Clinic\uff0c\u6211\u4eec\u5c06\u9ec4\u8910\u6591\u89c6\u4e3a\u4e00\u79cd\u201c\u76ae\u80a4\u751f\u6001\u7cfb\u7edf\u75be\u75c5\u201d\u3002

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Scientific References
1. Kim JY, et al. Senescent fibroblasts in melasma pathophysiology. Experimental Dermatology. 2018;27(7):719-722.
2. Passeron T. Melasma pathogenesis and influencing factors \u2013 an overview of the latest research. Journal of the European Academy of Dermatology and Venereology. 2013;27(Suppl 1):5-6.
3. Kang HY, et al. The pathophysiology of melasma. Journal of Investigative Dermatology Symposium Proceedings. 2009;14(1):4-8.
4. Grimes PE. Melasma: Etiologic and therapeutic considerations. Archives of Dermatology. 1995;131(12):1453-1457.
5. Torres-\u00c1lvarez B, et al. Histochemical and immunohistochemical study in melasma: Evidence of damage in the basal membrane. American Journal of Dermatopathology. 2011;33(3):291-295.
6. Lee DJ, et al. Defective barrier function in melasma skin. Journal of the European Academy of Dermatology and Venereology. 2012;26(12):1538-1543.
7. Handel AC, Miot LDB, Miot HA. Melasma: A clinical and epidemiological review. Anais Brasileiros de Dermatologia. 2014;89(5):771-782.<\/pre>","protected":false},"excerpt":{"rendered":"
By Dr. Piyawat POOMSUWAN , Dr.Tiwanun PROMVARANON \u987d\u56fa\u6027\u9ec4\u8910\u6591\u7684\u9690\u85cf\u771f\u76f8 \u4e3a\u4ec0\u4e48\u6cbb\u7597\u591a\u5e74\uff0c\u9ec4\u8910\u6591\u4ecd\u7136\u53cd\u590d\u51fa\u73b0\uff1f \u9ec4\u8910\u6591\u4e0d\u4ec5\u4ec5\u662f\u8272\u7d20\u95ee\u9898 \u8fd1\u5e74\u6765\u76ae\u80a4\u79d1\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u9ec4\u8910\u6591\u4e0d\u4ec5\u662f\u8868\u76ae\u8272\u7d20\u6c89\u7740\u7684\u95ee\u9898\uff0c\u66f4\u662f\u4e00\u79cd\u4e0e\u5149\u8001\u5316\u76f8\u5173\u7684\u76ae\u80a4\u75be\u75c5\u3002 \u4e5f\u5c31\u662f\u8bf4\uff0c\u9ec4\u8910\u6591\u4e0d\u4ec5\u5b58\u5728\u4e8e\u8868\u76ae\uff0c\u8fd8\u6d89\u53ca\u771f\u76ae\u5c42\u7684\u7ed3\u6784\u53d8\u5316\u3002 \u4f20\u7edf\u5bf9\u9ec4\u8910\u6591\u7684\u8ba4\u8bc6 \u8fc7\u53bb\u8ba4\u4e3a\u9ec4\u8910\u6591\u4e3b\u8981\u662f\u7531\u4e8e\u9ed1\u8272\u7d20\u7ec6\u80de\u8fc7\u5ea6\u6d3b\u8dc3\uff0c\u4ea7\u751f\u8fc7\u591a\u9ed1\u8272\u7d20\u3002 \u56e0\u6b64\u6cbb\u7597\u4e3b\u8981\u96c6\u4e2d\u5728\uff1a\u2022 \u7f8e\u767d\u836f\u7269\u2022 \u6291\u5236\u9ed1\u8272\u7d20\u751f\u6210\u7684\u62a4\u80a4\u54c1\u2022 \u6fc0\u5149\u6cbb\u7597 \u8fd9\u4e9b\u65b9\u6cd5\u53ef\u4ee5\u6682\u65f6\u6de1\u5316\u8272\u6591\uff0c\u4f46\u5f80\u5f80\u96be\u4ee5\u9632\u6b62\u590d\u53d1\u3002 \u771f\u6b63\u7684\u539f\u56e0\uff1a\u771f\u76ae\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de \u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u9ec4\u8910\u6591\u76ae\u80a4\u4e2d\u5b58\u5728\u5927\u91cf\u201c\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u3002 \u8fd9\u4e9b\u8001\u5316\u7ec6\u80de\u529f\u80fd\u5f02\u5e38\uff0c\u88ab\u8ba4\u4e3a\u662f\u5bfc\u81f4\u9ec4\u8910\u6591\u6301\u7eed\u5b58\u5728\u7684\u91cd\u8981\u539f\u56e0\u3002 \u8fd9\u4e9b\u7ec6\u80de\u4e3a\u4f55\u4f1a\u51fa\u73b0 \u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e3b\u8981\u7531\u4ee5\u4e0b\u56e0\u7d20\u9020\u6210\uff1a \u2022 \u957f\u671f\u7d2b\u5916\u7ebf\u7167\u5c04\u2022 \u5149\u8001\u5316\u2022 \u81ea\u7136\u8870\u8001\u2022 \u73af\u5883\u6c61\u67d3 \u8fd9\u4e9b\u7ec6\u80de\u4f1a\u91ca\u653e\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u548c\u708e\u75c7\u56e0\u5b50\uff0c\u523a\u6fc0\u9ed1\u8272\u7d20\u7ec6\u80de\u4ea7\u751f\u66f4\u591a\u9ed1\u8272\u7d20\u3002 \u4e3a\u4ec0\u4e48\u6fc0\u5149\u6709\u65f6\u4f1a\u8ba9\u9ec4\u8910\u6591\u53d8\u4e25\u91cd \u5982\u679c\u6cbb\u7597\u53ea\u9488\u5bf9\u8272\u7d20\uff0c\u800c\u6ca1\u6709\u6539\u5584\u76ae\u80a4\u6df1\u5c42\u73af\u5883\uff0c\u6fc0\u5149\u6cbb\u7597\u540e\u53ef\u80fd\u51fa\u73b0\uff1a \u2022 \u53cd\u5f39\u6027\u9ec4\u8910\u6591\u2022 \u708e\u75c7\u540e\u8272\u7d20\u6c89\u7740\uff08PIH\uff09 \u9ec4\u8910\u6591\u6cbb\u7597\u7684\u65b0\u7406\u5ff5 \u73b0\u4ee3\u9ec4\u8910\u6591\u6cbb\u7597\u5f3a\u8c03\u540c\u65f6\u6539\u5584\u4e09\u4e2a\u5c42\u9762\uff1a 1. \u63a7\u5236\u9ed1\u8272\u7d20\u751f\u62102. \u63a7\u5236\u708e\u75c7\u53cd\u5e943. \u771f\u76ae\u5c42\u5e74\u8f7b\u5316 \u901a\u8fc7\u6062\u590d\u76ae\u80a4\u5fae\u73af\u5883\u7684\u5e73\u8861\uff0c\u624d\u80fd\u51cf\u5c11\u590d\u53d1\u3002 Piyawat Clinic\u7684\u6cbb\u7597\u7406\u5ff5 \u5728Piyawat Clinic\uff0c\u6211\u4eec\u5c06\u9ec4\u8910\u6591\u89c6\u4e3a\u4e00\u79cd\u201c\u76ae\u80a4\u751f\u6001\u7cfb\u7edf\u75be\u75c5\u201d\u3002 \u6cbb\u7597\u4e0d\u4ec5\u9488\u5bf9\u8272\u7d20\uff0c\u8fd8\u4f1a\u4ece\u591a\u5c42\u6b21\u6539\u5584\u76ae\u80a4\u6574\u4f53\u73af\u5883\uff0c\u4ece\u800c\u83b7\u5f97\u66f4\u7a33\u5b9a\u3001\u6301\u4e45\u7684\u6cbb\u7597\u6548\u679c\u3002 \u6bcf\u4e2a\u4eba\u7684\u808c\u80a4\u95ee\u9898\u5404\u4e0d\u76f8\u540c\u3002\u5efa\u8bae\u54a8\u8be2\u4e13\u4e1a\u533b\u751f\uff0c\u8fdb\u884c\u5168\u9762\u8bc4\u4f30\uff0c\u5e76\u5236\u5b9a\u4e13\u5c5e\u4e8e\u60a8\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\u3002 Scientific References1. Kim JY, et al. Senescent […]<\/p>\n","protected":false},"author":1,"featured_media":1827,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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